Many BPA-free bottles contain a chemical that causes arrhythmia

Many BPA-free bottles contain a chemical that causes arrhythmia

A chemical found in many products labeled "BPA free" may produce many of the same health problems as the original chemical, including hyperactivity and cardiac arrhythmia, according to a pair of studies presented recently at the joint meeting of the International Society of Endocrinology and the Endocrine Society in Chicago.

"BPS, termed the safe alternative to BPA, may be equally as harmful to developing brains," said Deborah Kurrasch of the University of Calgary, lead researcher of one of the studies. "Society must place increased pressure on decision makers to remove all bisphenol compounds from manufacturing processes."

The "Safer" alternative is not so safe

Bisphenol A, or BPA, is a widely used chemical that is a known hormone disrupter and has been linked to health conditions as diverse as cancer, obesity, hyperactivity and reproductive problems.

Growing concern over the health effects of BPA has led many manufacturers to introduce "BPA free" products. Yet many -- although not all -- of these products rely on a closely related chemical, bisphenol S (BPS).

"BPS is one of the substitutes used in BPA-free products," said Hong-Sheng Wang of the University of Cincinnati, lead researcher of the second study. "There is implied safety in BPA-free products. The thing is, the BPA analogs -- and BPS is one of them -- have not been tested for safety in humans."

BPS disrupts multiple hormone pathways

In the first study, Kurrasch and her colleagues found that zebrafish that were exposed to BPS became hyperactive in a similar manner to those exposed to BPAhttp://dreddyclinic.com/forum/viewtopic.php?f=11&t=32616.

The study was designed to simulate prenatal chemical exposure, such as would occur in pregnant women exposed to BPA or BPS. Researchers exposed zebrafish embryos to the same BPA concentrations found in Alberta's Oldman River, a major drinking water source. They then counted how many neurons developed in the brain.

The researchers found that fish exposed to BPA had 170% more neurons at the time of peak neuronal birth than fish not exposed to any chemicals. Fish exposed to equivalent concentrations of BPS had 240% more. In addition, both BPA- and BPS-exposed fish demonstrated hyperactive behavior (as determined by movement tracking software) in a way that fish in non-exposed control groups did not.

The second study, which Wang called, "one of the first assessments of BPS' effect in mammalian primary cells or organs," found that BPS produced arrhythmiahttp://dreddyclinic.com/findinformation/hh/heartarrhythmias.php -- abnormalities in heart rhythm -- in a similar manner to BPA.

Researchers exposed approximately 50 rats to a 1-nanomolar dose of BPS, roughly equivalent to the concentrations that prior studies have found in human urine. The rats' hearts were stimulated with the hormone catecholamine to mimic a natural stress response, and then BPS was sent flowing through the arteries and into the pumping heart. A control group of 30 rats was treated with catecholamine, but not with BPS.

The researchers found that the hearts of the female rats (but not the male rats) exposed to BPS exhibited a rapid heartbeat (ventricular tachycardia) and extra heartbeats. This problem seemed to occur because BPS caused abnormal calcium cycling in a manner similar to that caused by BPA.

When the researchers blocked the estrogen receptors in the female rats, the BPS-induced arrhythmia eased, confirming an estrogen-mimicking role for BPS, much like BPA.

Notably, the Calgary researchers found that BPA, and perhaps also BPS, might disrupt hormones through pathways other than by mimicking estrogen. In the zebrafish study, BPA actually appeared to mimic testosterone, a predominantly male sex hormone http://www.dreddyclinic.com/forum/viewtopic.php?f=31&t=33259.

Wang's summary of the Cincinnati research could easily apply to both studies: "Our findings call into question the safety of BPA-free products containing BPS," he said. "BPS and other BPA analogs need to be evaluated before further use by humans."

Sources for this article include:

http://www.newswise.com/

http://www.newswise.com/articles/common-bpa-like-chemical-bps-disrupts-heart-rhythms-in-females

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Plastics chemicals cause infertility and health

Plastics chemicals cause infertility and health

An infertility crisis on Spanish pig farms has been linked to endocrine-disrupting plastic chemicals also found in human food products, in a study conducted by researchers from the University of Zaragoza and published in the journal Scientific Reports in May.

The study marks "the first time that the correlation between reproductive failures and compounds migrating from plastic materials [has been] studied and demonstrated," lead researcher Cristina Nerin said.

Semen bags contaminated

In the spring of 2010, sows on 41 separate pig farms across Spain abruptly stopped bearing young or began producing smaller-than-normal litters. Researchers examined both the sows and the semen that had been used to artificially inseminate them but found no abnormalities or evidence of disease and no evidence of feed or water contamination.

They did eventually discover, however, that all the semen used in inseminating sows on the farms had been originally refrigerated in bags that came from the same company.

Nerin, an expert in food packaging, was called in by the bag-making company to solve the mystery. Her preliminary tests identified several chemicals in the bags that have been linked to endocrine (hormone) disruption and reproductive problems, most notably cyclic lactone and BADGE.

Cyclic lactone is commonly used in the adhesives used to seal food bags, such as bags of potato chips or sliced meat. It was among the chemicals found at highest concentrations in the semen bags. BADGE, a byproduct of the notorious chemical bisphenol A (BPA), was also found at high levels.

BPA and BADGE are both found in high levels not just in hard plastics but also in the linings of 95 percent of food and beverage cans on the market. BADGE is also found in household dust.

Both cyclic lactone and BADGE have been shown, in prior studies, to migrate from packaging into food. A recent study by the New York State Department of Health found BADGE in 100 percent of urine samples collected in the United States and China. Read more